Among the diseases of the retina of unknown or idiopathic origin, the most frequent is central serous choroidopathy. This disease is located in the macula and is produced by an alteration in a layer of the retina referred to as the pigment epithelium of the retina (EPR). The EPR has a barrier function which it appears to lose due to the increase of a hormone called cortisol. The increase in cortisol, which is produced in situations as for example, stress, induces an increase of permeability and a "flooding" of the retina due to the passage of fluid from the retinal pigment epithelium. Generally, the disorder is self-limited and fluid is absorbed spontaneously, however eventually, if visual acuity does not recover and the fluid persists, treatment with laser on the leakage points in the EPR is recommended.