{"id":170,"date":"2026-02-04T14:00:28","date_gmt":"2026-02-04T14:00:28","guid":{"rendered":"https:\/\/www.barnaclinic.com\/blog\/oncologia\/?p=170"},"modified":"2026-02-04T14:00:28","modified_gmt":"2026-02-04T14:00:28","slug":"avencos-cancer-pancrees-pronostic-esperanca-vida","status":"publish","type":"post","link":"https:\/\/www.barnaclinic.com\/blog\/oncologia\/ca\/avencos-cancer-pancrees-pronostic-esperanca-vida\/","title":{"rendered":"Nous aven\u00e7os en c\u00e0ncer de p\u00e0ncrees: com poden canviar el pron\u00f2stic i l\u2019esperan\u00e7a de vida"},"content":{"rendered":"

El c\u00e0ncer de p\u00e0ncrees<\/strong> continua sent un dels tumors amb pitjor pron\u00f2stic en oncologia. La dificultat de detectar-lo en fases inicials i l\u2019efic\u00e0cia limitada dels tractaments actuals expliquen que l\u2019esperan\u00e7a de vida del c\u00e0ncer de p\u00e0ncrees<\/strong> continu\u00ef sent baixa, especialment en estadis avan\u00e7ats o amb met\u00e0stasi.<\/p>\n

En aquest context, els resultats precl\u00ednics publicats recentment per l\u2019equip del Dr. Mariano Barbacid, del Centro Nacional de Investigaciones Oncol\u00f3gicas (CNIO)<\/a>, han generat un notable inter\u00e8s cient\u00edfic: una ter\u00e0pia triple dirigida contra KRAS<\/strong> va aconseguir eliminar tumors de c\u00e0ncer de p\u00e0ncrees en models murins, evitant tamb\u00e9 l\u2019aparici\u00f3 de resist\u00e8ncies.<\/p>\n

Per entendre l\u2019abast real d\u2019aquests aven\u00e7os des del punt de vista cl\u00ednic, la Dra. Teresa Macarulla<\/strong><\/a>, onc\u00f2loga de barnacl\u00ednic+ i cap del Servei d\u2019Oncologia M\u00e8dica de l\u2019Hospital Cl\u00ednic de Barcelona, aporta una visi\u00f3 experta i rigorosa.<\/p>\n

\n

Investigaci\u00f3 en c\u00e0ncer de p\u00e0ncrees: qu\u00e8 aporten els nous estudis<\/h2>\n

L\u2019estudi del CNIO se centra en l\u2019adenocarcinoma ductal pancre\u00e0tic<\/strong>, el tipus m\u00e9s freq\u00fcent de c\u00e0ncer de p\u00e0ncrees, caracteritzat per la seva elevada agressivitat i resist\u00e8ncia als tractaments.<\/p>\n

La Dra. Macarulla subratlla la import\u00e0ncia de contextualitzar aquests resultats i evitar interpretacions err\u00f2nies: \u201cEls resultats s\u00f3n molt interessants, per\u00f2 encara molt preliminars, perqu\u00e8 s\u00f3n dades de models murins, no de pacients\u201d<\/strong>. Aquest mat\u00eds \u00e9s clau, especialment per a les persones que busquen respostes sobre si el c\u00e0ncer de p\u00e0ncrees t\u00e9 cura<\/strong> o si \u00e9s possible curar el c\u00e0ncer de p\u00e0ncrees<\/strong> amb noves ter\u00e0pies fora del context experimental.<\/p>\n

\n


\n\"Teresa
\n\u201cEls resultats s\u00f3n molt interessants, per\u00f2 encara molt preliminars, perqu\u00e8 s\u00f3n dades de models murins, no de pacients\u201d
\n<\/strong><\/h4>\n

Dra. Teresa Macarulla<\/strong><\/a> \u2013 Onc\u00f2loga de barnacl\u00ednic+ i cap del Servei d\u2019Oncologia M\u00e8dica de l\u2019Hospital Cl\u00ednic de Barcelona<\/p><\/blockquote>\n

\n
\n

Per ampliar informaci\u00f3 cl\u00ednica fiable, tamb\u00e9 es pot consultar la p\u00e0gina de l\u2019Hospital Cl\u00ednic de Barcelona sobre el c\u00e0ncer de p\u00e0ncrees<\/a>.<\/p>\n<\/div>\n<\/div>\n

Del laboratori als pacients: efic\u00e0cia i seguretat<\/h3>\n

En oncologia, demostrar que una estrat\u00e8gia funciona en models animals \u00e9s nom\u00e9s el primer pas. El seg\u00fcent repte \u00e9s traslladar aquests resultats a la pr\u00e0ctica cl\u00ednica mitjan\u00e7ant assaigs controlats en humans.<\/p>\n

Tal com explica la Dra. Macarulla, primer cal comprovar que la ter\u00e0pia funciona en models murins i, posteriorment, \u201ctestar l\u2019estrat\u00e8gia en humans i demostrar-ne l\u2019efic\u00e0cia, per\u00f2 tamb\u00e9 comprovar la seguretat de la ter\u00e0pia en pacients\u201d<\/strong>. Aquest proc\u00e9s \u00e9s especialment exigent en el c\u00e0ncer de p\u00e0ncrees, una malaltia per a la qual la superviv\u00e8ncia del c\u00e0ncer de p\u00e0ncrees<\/strong> continua sent limitada.<\/p>\n

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Tractament del c\u00e0ncer de p\u00e0ncrees i pron\u00f2stic actual<\/h2>\n

El pron\u00f2stic del c\u00e0ncer de p\u00e0ncrees<\/strong> continua sent desfavorable en molts casos, principalment a causa del diagn\u00f2stic tard\u00e0. La malaltia sol ser silenciosa en fases inicials i els s\u00edmptomes preco\u00e7os no sempre s\u00f3n clars ni espec\u00edfics (per exemple, algunes persones busquen dos senyals primerencs de c\u00e0ncer de p\u00e0ncrees<\/strong>).<\/p>\n

Segons la Dra. Macarulla, \u201cla gran dificultat del c\u00e0ncer de p\u00e0ncrees \u00e9s que la malaltia \u00e9s silenciosa en la fase inicial i, per tant, la majoria dels pacients es diagnostiquen en fases avan\u00e7ades\u201d<\/strong>.<\/p>\n

Actualment, \u201cl\u2019\u00fanica arma que tenim per tractar la malaltia \u00e9s la quimioter\u00e0pia, amb resultats moderats\u201d. Per aix\u00f2, con\u00e8ixer les opcions de tractament del c\u00e0ncer de p\u00e0ncrees<\/strong><\/a> i l\u2019abordatge m\u00e9s adequat en cada fase \u00e9s clau per orientar expectatives realistes sobre superviv\u00e8ncia<\/strong> i esperan\u00e7a de vida<\/strong>, especialment en casos avan\u00e7ats o amb met\u00e0stasi.<\/p>\n

Cirurgia del c\u00e0ncer de p\u00e0ncrees: quan es busca un objectiu curatiu<\/h3>\n

En casos seleccionats i quan el tumor \u00e9s resecable, la cirurgia pot oferir una opci\u00f3 amb intenci\u00f3 curativa. No obstant aix\u00f2, aquesta possibilitat dep\u00e8n de l\u2019estadi de la malaltia, de l\u2019estat general del pacient i de la viabilitat t\u00e8cnica de la intervenci\u00f3.<\/p>\n

Si vols ampliar informaci\u00f3 sobre aquest abordatge, pots consultar la Unitat de Cirurgia del P\u00e0ncrees de barnacl\u00ednic+<\/strong><\/a> i els continguts espec\u00edfics del nostre blog.<\/p>\n

\n

A barnacl\u00ednic+ abordem aquests casos des d\u2019una unitat altament especialitzada:<\/h4>\n

Es pot eliminar el c\u00e0ncer de p\u00e0ncrees amb cirurgia?<\/strong><\/a><\/h4>\n

Objectiu de la cirurgia de p\u00e0ncrees<\/strong><\/a><\/h4>\n

M\u00e9s articles sobre c\u00e0ncer de p\u00e0ncrees<\/strong><\/a><\/h4>\n<\/div>\n
\n

Assaigs cl\u00ednics i inhibidors de KRAS: una esperan\u00e7a amb rigor<\/h2>\n

Un dels aspectes m\u00e9s prometedors de l\u2019estudi del CNIO \u00e9s el paper del gen KRAS<\/strong>, mutat en la majoria dels casos de c\u00e0ncer de p\u00e0ncrees i clau en el desenvolupament del tumor. La Dra. Macarulla destaca que aquesta estrat\u00e8gia \u201cja \u00e9s a la cl\u00ednica en assaigs cl\u00ednics\u201d i que \u201cels resultats preliminars en pacients amb c\u00e0ncer de p\u00e0ncrees s\u00f3n molt esperan\u00e7adors\u201d.<\/p>\n

Des del punt de vista de l\u2019especialista, el missatge per a pacients i familiars ha de ser d\u2019esperan\u00e7a, per\u00f2 amb realisme: els aven\u00e7os s\u00f3n rellevants, per\u00f2 encara no permeten afirmar que el c\u00e0ncer de p\u00e0ncrees t\u00e9 cura<\/strong> en la pr\u00e0ctica cl\u00ednica general.<\/p>\n

A m\u00e9s, confirma que els assaigs cl\u00ednics amb noves estrat\u00e8gies terap\u00e8utiques estaran oberts al nostre centre durant l\u2019any 2026<\/strong>, cosa que permetr\u00e0 a determinats pacients accedir a tractaments innovadors dins d\u2019un entorn altament especialitzat.<\/p>\n

\n

C\u00e0ncer de p\u00e0ncrees avui: investigaci\u00f3 que avan\u00e7a, atenci\u00f3 especialitzada<\/h2>\n

Tot i que avui dia no es pot afirmar que el c\u00e0ncer de p\u00e0ncrees t\u00e9 cura<\/strong>, els aven\u00e7os en investigaci\u00f3 estan posant les bases per millorar el pron\u00f2stic<\/strong>, la superviv\u00e8ncia del c\u00e0ncer de p\u00e0ncrees<\/strong> i la qualitat de vida dels pacients, especialment quan es combinen atenci\u00f3 experta, tractaments personalitzats i acc\u00e9s a assaigs cl\u00ednics.<\/p>\n

A barnacl\u00ednic+, apostem per una atenci\u00f3 integral basada en el rigor cient\u00edfic, l\u2019acc\u00e9s a la innovaci\u00f3 terap\u00e8utica i la col\u00b7laboraci\u00f3 amb centres de refer\u00e8ncia com l\u2019Hospital Cl\u00ednic de Barcelona.<\/p>\n

\n
\n

SI DESITGES M\u00c9S INFORMACI\u00d3 SOBRE EL C\u00c0NCER DE P\u00c0NCREES, EL SEU TRACTAMENT O EL SEU DIAGN\u00d2STIC, EL NOSTRE EQUIP ET POT AJUDAR<\/span><\/h4>\n


\nDEMANAR CITA
\n<\/a><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

El c\u00e0ncer de p\u00e0ncrees continua sent un dels tumors amb pitjor pron\u00f2stic en oncologia. La dificultat de detectar-lo en fases inicials i l\u2019efic\u00e0cia limitada dels tractaments actuals expliquen que l\u2019esperan\u00e7a de vida del c\u00e0ncer de p\u00e0ncrees continu\u00ef sent baixa, especialment en estadis avan\u00e7ats o amb met\u00e0stasi. En aquest context, els resultats precl\u00ednics publicats recentment per […]<\/p>\n","protected":false},"author":2,"featured_media":162,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[164],"tags":[170,165,167,166,168,169,174,171,172,173,175,176],"yoast_head":"\nNovetats en c\u00e0ncer de p\u00e0ncrees: pron\u00f2stic i esperan\u00e7a de vida<\/title>\n<meta name=\"description\" content=\"La Dra. 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